Presumptive Development of Fibrotic Lung Disease From Bordetella bronchiseptica and Post-infectious Bronchiolitis Obliterans in a Dog

Presumptive Development of Fibrotic Lung Disease From Bordetella bronchiseptica and Post-infectious Bronchiolitis Obliterans in a Dog

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A 7-month-old Miniature Poodle acquired from a pet store developed cough and subsequently respiratory distress compatible with Bordetella bronchiseptica infection.Partial but incomplete resolution of clinical signs and thoracic radiographic/computed tomographic imaging bovi-shield gold fp 5 l5 lesions were noted with use of susceptibility-guided antimicrobials.Additionally, a concern for an infectious nidus led to left cranial lung lobectomy at 9 months of age.

Histopathology predominantly revealed polypoid and constrictive bronchiolitis obliterans (i.e., small airway disease).

Intermittent antimicrobial administration over the next 5 years failed to blunt progressive clinical signs.At 8 years, necropsy confirmed severe airway-centered interstitial fibrosis.This pattern of fibrosis was strongly suggestive of underlying small airway disease as the trigger.

In retrospect, post-infectious bronchiolitis obliterans (PIBO), a syndrome in young children caused by pulmonary infections but not yet recognized in pet dogs, likely initiated a pathway of fibrosis in this dog.In dogs with risk factors for community-acquired pathogens such as Bordetella bronchiseptica, PIBO is a differential diagnosis with development of severe, persistent respiratory signs incompletely responsive to appropriate antimicrobials.Untreated PIBO may lead to airway-centered interstitial fibrosis.

Future study is required to determine if targeted therapy of PIBO could alter the grand love red heart reposado tequila course of end-stage pulmonary fibrosis.